Interleukins: New Tool in Immunology

New developments in allotransplant immunology.

After allogeneic stem cell transplantation, the establishment of the donor's immune system in an antigenically distinct recipient confers a therapeutic graft-versus-malignancy effect, but also causes graft-versus-host disease (GVHD) and protracted immune dysfunction. In the last decade, a molecular-level description of alloimmune interactions and the process of immune recovery leading to tolera...

Tumor immunology: new perspectives.

This second meeting, organized by the Cancer Immunology Working Group of AACR, concentrated mainly on three areas of importance; these included (a) ways to increase the success rate of vaccination by improving the peptides themselves, improving tumor recognition by using costimulatory molecules or the use of antibodies; (b) how the tumor microenvironment influences T-cell activity and how it ca...

Microenvironment and Immunology CXM: A New Tool for Mapping Breast Cancer Risk in the Tumor Microenvironment

Themajority of causative variants in familial breast cancer remain unknown. Of the known risk variants, most are tumor cell autonomous, and little attention has been paid yet to germline variants that may affect the tumor microenvironment. In this study, we developed a system called the Consomic Xenograft Model (CXM) to map germline variants that affect only the tumormicroenvironment. In CXM, h...

The transplanted tumor as a research tool in cancer immunology.

Much has been written about the promises, disappointments, and snares for the inexperienced and uninformed in the use of the transplanted tumor as a model in the search for a prophylaxis and immunotherapy of cancer (10, 12, 14, 21, 33, 87, 46, 49, 56). Despite the repeated warnings of the necessary precautions in experimental design, misguided reports of the detection or achievement of "cancer ...

The interleukins in acquired disease.